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Using one-molecule optical and AFM imaging and pressure-spectroscopy tactics, we seek out to unravel the mechanistic elements of the framework and dynamics of chromosomes. Our exploration passions incorporate:

It was only while in the 1990s although, when nanotechnology had Highly developed into a level the place single molecules may be manipulated, that the first experimental units commenced to appear.

Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

This yielded a breakthrough. Within just a few months, we had been able to measure transportation by way of an individual solitary-walled carbon nanotube. According to very low-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies having an active research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with pretty extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

Our study ranges in the biophysics of DNA to synthetic cells and over and above. Remember to have a look beneath on the spectrum of our existing tasks.

All parameters were a similar for each panel Within this video clip, apart from the First placement with the 6hb rod (revealed in blue) on the nanopore. Simulations that terminated early as a result of translocation on the rod from the pore are marked by a gray qualifications.

2011, initial in vitro measurements of transport throughout only one biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the mechanism of homology recognition in DNA homologous recombination

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1). The existing–voltage curves showed sizeable modulations with gate voltage, even at area temperature, which was consistent with band bending in the ~0.6 eV bandgap semiconducting nanotube. These knowledge also confirmed which the conductance might be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a room-temperature transistor made from a single carbon nanotube molecule — have been posted in Nature in May well 1998.

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Nanoscientist Cees Dekker is definitely an amiable and flamboyant guy who seems Substantially youthful as opposed to 62 a long time he really is – fashionable Eyeglasses, psychedelic shirt, participating smile – but not one to squander time. He normally takes his time, but no more than necessary.

2008, initially observation of cees dekker protein-coated DNA translocation through nanopores; resolved the origin of the electrophoretic drive on DNA in nanopores; found out an important velocity maximize of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid

2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes